Immune Functions in Peripheral Tissues

Grant number: 1059514 | Funding period: 2014 - 2016

Completed

Abstract

Protection from infections relies on different types of immune cells. While some of these cells are found in the blood, others reside in peripheral tissues such as the skin. We will analyse the function of these peripheral immune cells to understand how they work to fight off infections. We will also investigate how so-called memory cells that permanently reside in peripheral tissues can protect from re-infection with similar bacteria or viruses.

Related publications (4)

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Ptpn2 and KLRG1 regulate the generation and function of tissue-resident memory CD8 T cells in skin

K Hochheiser, F Wiede, T Wagner, D Freestone, MH Enders, M Olshansky, B Russ, S Nüssing, E Bawden, A Braun, A Bachem, E Gressier, R McConville, SL Park, CM Jones, GM Davey, DE Gyorki, D Tscharke, IA Parish, S Turner

2021-04-29

Tissue-resident memory T cells (T<inf>RM</inf> cells) are key elements of tissue immunity. Here, we investigated the role of the r..

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Tissue-resident memory T cells in tissue homeostasis, persistent infection, and cancer surveillance

T Gebhardt, U Palendira, DC Tscharke, S Bedoui

2018-05-01

A large proportion of memory T cells disseminated throughout the body are non-recirculating cells whose maintenance and function i..

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Effective priming of herpes simplex virusspecific CD8 T cells in vivo does not require infected dendritic cells

PG Whitney, C Makhlouf, B MacLeod, JZ Ma, E Gressier, M Greyer, K Hochheiser, A Bachem, A Zaid, D Voehringer, WR Heath, MV Wagle, I Parish, TA Russell, SA Smith, DC Tscharke, T Gebhardt, S Bedoui

2018-02-01

Resolution of virus infections depends on the priming of virus-specific CD8<sup>+</sup> T cells by dendritic cells (DC). While thi..

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Distinct APC Subtypes Drive Spatially Segregated CD4 and CD8 T-Cell Effector Activity during Skin Infection with HSV-1

BL Macleod, S Bedoui, JL Hor, SN Mueller, TA Russell, NA Hollett, WR Heath, DC Tscharke, AG Brooks, T Gebhardt

2014-08-14

Efficient infection control requires potent T-cell responses at sites of pathogen replication. However, the regulation of T-cell e..

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